Heung-min Son returns to the Tottenham side after suspension and replaces Christian Eriksen, who is dropped to the bench.
Dele Alli is still out and so too is Tanguy Ndombele, who has suffered a thigh strain in training and is replaced by Lucas Moura.
Newcastle forward Joelinton is fit to play despite picking up a slight hip injury against Norwich.
Tottenham: Lloris, Walker-Peters, Alderweireld, Sanchez, Rose, Winks, Sissoko, Lamela, Lucas, Son, Kane
Subs: Gazzaniga, Vertonghen, Dier, Lo Celso, Eriksen, Skipp, Davies
Newcastle: Dubravka, Krafth, Schar, Lascelles, Dummett, Hayden, Longstaff, Almiron, Sant-Maximin, Ritchie, Joelinton
Subs: Darlow, Shelvey, Muto, Willems, Fernandez, Manquillo, Atsu