Juan Foyth has been brought into the Tottenham team as part of a five-man defence for the Champions League clash at Wembley.
Serge Aurier has also been brought in, as have Toby Alderweireld and Lucas Moura.
Heung-Min Son leads the attack with Moura and Christian Eriksen in support.
Tottenham: Lloris, Aurier, Alderweireld, Sanchez, Foyth, Vertonghen, Winks, Sissoko, Eriksen, Lucas, Son.
Subs: Gazzaniga, Trippier, Rose, Skipp, Wanyama, Lamela, Llorente.
Borussia Dortmund: Burki, Hakimi, Zagadou, Diallo, Schmelzer, Witsel, Delaney, Dahoud, Sancho, Pulisic, Gotze.
Subs: Hitz, Guerreiro, Balerdi, Philipp, Wolf, Schmelzer, Larsen.