Recent signings Gareth Bale and Carlos Vinicius are both on the bench for Tottenham, who are without Eric Dier.
There are two Spurs changes: Toby Alderweireld is in for Dier and the fit-again Steven Bergwijn comes in for Lucas Moura, who drops to the bench.
West Ham are unchanged. They have Issa Diop and Ryan Fredericks available again but both are substitutes.
Tottenham: Lloris, Aurier, Alderweireld, Sanchez, Reguilon, Ndombele, Sissoko, Hojbjerg, Bergwijn, Kane, Son.
Subs: Hart, Doherty, Davies, Winks, Moura, Vinicius, Bale.
West Ham: Fabianski, Ogbonna, Balbuena, Cresswell, Coufal, Rice, Soucek, Masuaku, Bowen, Antonio, Fornals.
Subs: Randolph, Fredericks, Diop, Noble, Snodgrass, Lanzini, Yarmolenko.