Juan Foyth makes his first league start of the season for Tottenham.
Davinson Sanchez is on the bench, as are Christian Eriksen and Son Heung-min.
Dele Alli is absent from Spurs’ matchday squad. Harry Winks comes in for the injured Eric Dier.
Wolves, meanwhile, are without winger Diogo Jota.
Wolves: Patricio, Bennett, Coady, Boly, Doherty, Neves, Moutinho, Jonny, Cavaleiro, Jimenez, Costa.
Subs: Ruddy, Gibbs-White, Vinagre, Hause, Dendoncker, Bonatini, Traore.
Tottenham: Lloris, Trippier, Alderweireld, Foyth, Davies, Sissoko, Dembele, Winks, Moura, Kane, Lamela.
Subs: Gazzaniga, Sanchez, Aurier, Skipp, Son, Eriksen, Llorente.