Son Heung-min has been dropped, with Richarlison replacing him in the Tottenham side for this afternoon’s London derby.
It is one of three changes made by Spurs from the midweek Champions League defeat against AC Milan.
The other changes are Ben Davies coming in at left wing-back for Ivan Perisic and Pierre-Emile Hojbjerg replacing Pape Sarr in midfield.
West Hma make two changes, with Tomas Soucek and Flynn Downes coming in for Said Benrahma and the injured Lucas Paqueta.
Tottenham: Forster; Romero, Dier, Lenglet; Royal, Hojbjerg, Skipp, Davies; Richarlison, Kulusevski, Kane.
Subs: Austin, Sanchez, Son, Perisic, Danjuma, Porro, Tanganga, Moura, Sarr.
West Ham: Fabianski; Kehrer, Ogbonna, Aguerd; Coufal, Soucek, Rice, Downes, Emerson; Antonio, Bowen.
Subs: Areola, Johnson, Cresswell, Scamacca, Fornals, Lanzini, Ings, Benrahma, Casey.