Dele Alli misses out for Tottenham, who start with Fernando Llorente up front in the absence of the injured Harry Kane, with Son Heung-min on the bench.
Alli has a hand injury and is sidelined along with Kane, Serge Aurier, Eric Dier and Erik Lamela.
Meanwhile, relegated Huddersfield are without Isaac Mbenza because of illness.
Tottenham: Lloris, Walker-Peters, Sanchez, Vertonghen, Foyth, Davies, Sissoko, Wanyama, Eriksen, Moura, Llorente
Subs: Gazzaniga, Trippier, Rose, Alderweireld, Son, Marsh, Skipp
Huddersfield: Hamer, Hadergjonaj, Kongolo, Schindler, Durm, Bacuna, Stankovic, Hogg, Lowe, Grant, Kachunga
Subs: Coleman, Smith, Mooy, Williams, Pritchard, Mounie, Zanka.
Follow London Football News: