Tottenham boss Jose Mourinho makes three changes from Wednesday’s 1-1 draw with Fulham.
Steven Bergwijn is fit again after illness and is recalled to the side along with Joe Rodon and Ben Davies.
Davinson Sanchez, Harry Winks and Moussa Sissoko drop to the bench.
Sheffield United make just one change; Enda Stevens comes in for Ben Osborn.
Sheffield United: Ramsdale, Basham, Egan, Ampadu, Bogle, Lundstram, Norwood, Fleck, Stevens, Burke, McGoldrick.
Subs: Foderingham, Baldock, Sharp, Lowe, Jagielka, Brewster, Bryan.
Tottenham: Lloris, Aurier, Rodon, Dier, Davies, Bergwijn, Hojbjerg, Ndombele, Reguilon, Son, Kane.
Subs: Hart, Alderweireld, Sanchez, Bale, Lamela, Sissoko, Moura, Gedson, Vinicius.