Tottenham make one change for the game at Bramall Lane, with Steven Bergwijn coming in for Dele Alli.
Alli drops to the bench, where he joins defenders Toby Alderweireld and Jan Vertonghen.
Sheffield United, meanwhile, are without the injured John Lundstram.
Tottenham: Lloris, Aurier, Sanchez, Dier, Davies, Sissoko, Lo Celso, Son, Bergwijn, Moura, Kane.
Subs: Gazzaniga, Alderweireld, Vertonghen, Winks, Ndombele, Skipp, Fernandes, Alli, Lamela.
Sheffield United: Henderson, Basham, Egan, Robinson, Baldock, Norwood, Berge, Osborn, McBurnie, McGoldrick.
Subs: Moore, Jagielka, Rodwell, K Freeman, Mousset, Zivkovic, Sharp.