Gareth Bale makes his first start for Tottenham since his recent return to the club.
Harry Kane and Son Heung-min are among the first-team regulars rested by boss Jose Mourinho for the Europa League Group J game.
There’s a recall for Dele Alli, who makes just his third start of the season.
Royal Antwerp: Butez, De Laet, Gelin, Seck, Juklerod, Hongla, Haroun, Gerkens, Miyoshi, Mbokani, Refaelov.
Tottenham: Lloris, Aurier, Sanchez, Davies, Reguilon, Winks, Dele, Lo Celso, Bergwijn, Bale, Vinicius.
Subs: Hart, Doherty, Alderweireld, Cirkin, Clarke, White, Sissoko, Hojbjerg, Lamela, Lucas, Son, Kane.