Tottenham make three changes to the side that started the 5-4 FA Cup defeat at Everton.
Harry Kane, Eric Dier and Japhet Tanganga come in for Steven Bergwijn, Toby Alderweireld and Matt Doherty.
Tanganga will make his first Premier League appearance of the season. Gareth Bale is on the bench.
Meanwhile, Sergio Aguero returns to the Manchester City squad and is on their bench.
Man City: Ederson, Cancelo, Stones, Laporte, Zinchenko, Rodri, Gundogan, Foden, Bernardo Silva, Sterling, Jesus.
Subs: Steffen, Walker, Dias, Aguero, Torres, Mendy, Mahrez, Garcia, Doyle.
Tottenham: Lloris, Tanganga, Dier, Sanchez, Davies, Ndombele, Hojbjerg, Lamela, Moura, Son, Kane.
Subs: Hart, Doherty, Alderweireld, Winks, Bale, Sissoko, Alli, Bergwijn, Vinicius.