Danny Rose has been restored to the Tottenham starting line-up for the game at the King Power Stadium, where Erik Lamela is among the substitutes.
Lamela is back in the squad after 13 months on the sidelines and having had surgery on both hips.
Spurs make four changes, with Serge Aurier, Moussa Sissoko and Mousa Dembele also being recalled.
Rose’s return means Ben Davies drops to the bench. Harry Winks misses out because of illness.
Meanwhile, Ben Chilwell and Shinji Okazaki are back in the Leicester side.
Tottenham: Lloris, Aurier, Sanchez, Vertonghen, Rose, Dier, Dembele, Sissoko, Eriksen, Dele, Kane.
Subs: Vorm, Davies, Foyth, Son, Trippier, Lamela, Llorente.
Leicester: Schmeichel, Simpson, Morgan, Maguire, Chilwell, Iborra, Ndidi, Mahrez, Albrighton, Okazaki, Vardy.
Subs: Hamer, Amartey, Dragovic, King, Choudhury, Gray, Slimani.