Davinson Sanchez has joined the Tottenham injury list and will miss the Champions League last-16 second leg at RB Leipzig.
Sanchez’s absence adds to Spurs’ injury woes – they were already without several players.
Japhet Tanganga comes into a back three and teenager Malachi Fagan-Walcott is among the Tottenham substitutes.
Tottenham: Lloris, Aurier, Alderweireld, Dier, Tanganga, Sessegnon, Winks, Lo Celso, Lamela, Moura, Alli.
Subs: Gazzaniga, Fagan-Walcott, Vertonghen, Skipp, Ndombele, Gedson Fernandes, Parrott.
RB Leipzig: Gulacsi, Angelino, Upamecano, Sabitzer, Werner, Klostermann, Nkunku, Schick, Mukiele, Halstenberg, Laimer.
Subs: Mvogo, Haidara, Poulsen, Forsberg, Adams, Lookman, Olmo.