Pierre-Emerick Aubameyang, Alexandre Lacazette and Nicolas Pepe all start for Arsenal in the derby at the Emirates Stadium, where Mesut Ozil is a substitute.
Meanwhile, Dele Alli is a substitute for Tottenham, who are without Eric Dier.
Dier has been struggling with a hip problem and was deemed not fit enough to be involved. Jan Vertonghen and Christian Eriksen are back in the Spurs starting line-up.
Davinson Sanchez is at right-back for Spurs as Kyle Walker-Peters has joined Juan Foyth, Tanguy Ndombele and Ryan Sessegnon on the sidelines.
Arsenal: Leno, Maitland-Niles, Sokratis, Luiz, Kolasinac, Torreira, Xhaka, Guendouzi, Pepe, Lacazette, Aubameyang.
Subs: Martinez, Mkhitaryan, Ceballos, Ozil, Chambers, Nelson, Willock.
Tottenham: Lloris, Sanchez, Vertonghen, Alderweireld, Rose, Winks, Eriksen, Sissoko, Lamela, Son, Kane.
Subs: Gazzaniga, Lo Celso, Alli, Aurier, Moura, Skipp, Davies.