Tottenham defenders Toby Alderweireld and Jan Vertonghen will both miss the London derby at Selhurst Park.
Alderweireld is nursing a hamstring strain, while Vertonghen has been ruled out after picking up a knock during a training session on Saturday.
Lucas Moura must wait for his first Premier League start – Spurs’ recent signing is among their substitutes.
Palace, who have a number of injury problems, give a debut to youngster Aaron Wan-Bissaka.
Crystal Palace: Hennessey, Wan-Bissaka, Fosu-Mensah, Tomkins, Van Aanholt, Milivojevic, Riedewald, McArthur, Townsend, Sørloth, Benteke.
Subs: Henry, Souare, Delaney, Rakip, Lokilo, Kirby, Lee.
Tottenham: Lloris, Aurier, Sanchez, Dier, Davies, Wanyama, Dembele, Lamela, Eriksen, Dele, Kane.
Subs: Vorm, Foyth, Trippier, Rose, Sissoko, Lucas, Son.