Marko Arnautović starts for West Ham in the London derby at the London Stadium, where Andy Carroll is on the Hammers bench.
The hosts have Mark Noble fit again but are without Pedro Obiang, who picked up a knock against West Brom.
Moussa Sissoko starts for Tottenham, while Ben Davies has fully recovered from a recent ankle injury and returns to the starting line-up.
West Ham: Hart, Zabaleta, Reid, Ogbonna, Fonte, Cresswell, Noble, Kouyate, Antonio, Arnautovic, Hernandez.
Subs: Adrian, Byram. Masuaku, Rice, Aye, Carroll, Sakho.
Tottenham: Lloris, Aurier, Alderweireld, Sanchez, Vertonghen, Davies, Dier, Sissoko, Eriksen, Dele, Kane.
Subs: Vorm, Trippier, Walker-Peters, Winks, Nkoudou, Son, Llorente.