Harry Kane is on the bench for Tottenham at White Hart Lane after recovering from the ankle injury that has ruled him out of the past three games.
Goalkeeper Hugo Lloris captains the side, having been passed fit after illness. Victor Wanyama has recovered from a back injury and joins Kane on the bench.
Watford make four changes, with Adrian Mariappa, Daryl Janmaat, Isaac Success and Stefano Okaka coming in for Troy Deeney and former Spurs man Etienne Capoue, who are both substitutes, and the injured Sebastian Prödl and suspended Miguel Britos.
Tottenham: Lloris, Trippier, Alderweireld, Vertonghen, Davies, Dier, Dembele, Son, Eriksen, Dele, Janssen
Subs: Lopez, Walker, Wimmer, Nkoudou, Sissoko, Wanyama, Kane.
Watford: Gomes; Mariappa, Cathcart, Holebas; Janmaat, Cleverley, Doucouré, Amrabat; Niang, Okaka, Success.
Subs: Pantilimon, Kabasele, Eleftheriou, Mason, Zúñiga, Capoue, Deeney.