Kieran Tripper has been passed fit for Tottenham, while Tiémoué Bakayoko makes his debut for Chelsea in the game at Wembley.
Alvaro Morata also starts for the Blues, who have included Bakayoko and Andreas Christensen in place of the suspended Cesc Fabregas and Gary Cahill.
Morata’s inclusion means Michy Batshuayi drops to the Chelsea bench, where he is joined by Pedro.
Tottenham: Lloris, Trippier, Alderweireld, Vertonghen, Davies, Dier, Wanyama, Dembele, Eriksen, Dele, Kane.
Subs: Vorm, Walker-Peters, Wimmer, Winks, Sissoko, Son, Janssen.
Chelsea: Courtois, Rudiger, Christensen, Azpilicueta, Luiz, Moses, Kante, Bakayoko, Alonso, Willian, Morata.
Subs: Caballero, Musonda, Kenedy, Scott, Tomori, Batshuayi, Pedro.