Tottenham are still without Toby Alderweireld for the game at St Mary’s.
Alderweireld had been expected to return from a back problem. Instead, Eric Dier continues at centre-back for Spurs.
Eric Lamela remains sidelined, but Danny Rose has been passed fit following a slight thigh problem. Victor Wanyama starts against his former club.
Southampton, meanwhile, have former Chelsea man Oriol Romeu back after suspension.
Southampton: Forster, Cedric, Fonte, Davis, Rodriguez, Romeu, Ward-Prowse, Van Dijk, Boufal, Bertrand, Redmond.
Subs: Taylor, Yoshida, Long, Tadic, Hojbjerg, Martina, Reed.
Tottenham: Lloris, Walker, Dier, Vertonghen, Rose, Wanyama, Dembele, Sissoko, Eriksen, Dele, Kane.
Subs: Vorm, Davies, Wimmer, Winks, Nkoudou, Son, Janssen.