Eric Dier is back in the Tottenham side following a hip injury but there is no Hugo Lloris in the matchday squad.
Spurs make five changes from the Champions League triumph at City, with Davinson Sanchez, Juan Foyth, and Ben Davies coming in along with Dier and keeper Paulo Gazzaniga.
Vincent Janssen, yet to feature this season, is on the bench for Spurs.
City, meanwhile, welcome back Oleksandr Zinchenko, who has been out with a hamstring injury. They make three changes, with Phil Foden and John Stones also coming in.
Man City: Ederson, Zinchenko, Laporte, Stones, Walker, Gundogan, Foden, De Bruyne, Bernardo Silva, Sterling, Aguero
Subs: Muric, Sane, David Silva, Fernandinho, Mahrez, Otamendi, Jesus
Tottenham: Gazzaniga, Davies, Alderweireld, Vertonghen, Sanchez, Dier, Foyth, Eriksen, Alli, Moura, Son.
Subs: Vorm, Rose, Janssen, Wanyama, Walker-Peters, Llorente, Skipp.