Rob Holding makes his Champions League debut as Arsenal reshuffle their line-up for the final group game away at FC Basel.
The 21-year-old summer arrival from Bolton replaces Shkodran Mustafi at centre-back, while Kieran Gibbs returns in place of Nacho Monreal.
They are among six changes to the side which won comprehensively at West Ham on Saturday.
Aaron Ramsey replaces Francis Coquelin in midfield, while Alex Iwobi and Lucas Perez play either side of Alexis Sanchez.
As with every Champions League game this season, David Ospina is preferred to Petr Cech in goal, while Granit Xhaka plays against his former club and lines up opposite his brother Taulent.
Basel include midfielder Matias Delgado, who has five goals in his last eight appearances, including scoring in their last two games.
Arsenal will top Group A if they can better Paris St-Germain’s result against Ludogorets.
FC Basel: Vaclik; Lang, Suchy, Balanta, Traore; Die, T. Xhaka; Elyounoussi, Delgado, Steffen; Janko.
Subs: Vailati, Gaber, Zuffi, Bjarnason, Hoegh, Calla, Doumbia.
Arsenal: Ospina; Gabriel, Holding, Koscielny, Gibbs; G. Xhaka, Ramsey; Iwobi, Ozil, Lucas; Sanchez.
Subs: Cech, Monreal, Mustafi, Elneny, Oxlade-Chamberlain, Walcott, Giroud.