Pierre-Emerick Aubameyang and Alexandre Lacazette both start for Arsenal at St James’ Park and there is a Premier League debut for teenager Joe Willock.
Aubameyang returns to the side after being cup-tied in the Europa League and boss Arsene Wenger has opted to deploy both Gunners strikers up front.
Granit Xhaka, who missed out against CSKA because of illness, returns for Arsenal but Jack Wilshere and Aaron Ramsey picked up knocks against the Russian side and are both absent.
Newcastle, meanwhile, are unchanged.
Newcastle: Dubravka, Yedlin, Lascelles, Lejeune, Dummett, Ritchie, Diame, Shelvey, Kenedy, Perez, Gayle.
Subs: Darlow, Clark, Murphy, Slimani, Hayden, Manquillo, Joselu.
Arsenal: Cech, Chambers, Mustafi, Holding, Monreal, Xhaka, Elneny, Willock, Iwobi, Lacazette, Aubameyang.
Subs: Ospina, Mertesacker, Welbeck, Maitland-Niles, Kolasinac, Nelson, Nketiah.