Arsenal are without the injured Alexandre Lacazette and Kieran Tierney’s wait for his Premier League debut goes on.
There had been speculation that summer signing Tierney might play at Old Trafford, but he is not in the matchday squad. Neither is Mesut Ozil.
Meanwhile, Paul Pogba and Marcus Rashford have been passed fit for United.
Aaron Wan-Bissaka misses out for the hosts and Axel Tuanzebe makes his first Premier League start since May 2017.
Man Utd: De Gea, Tuanzebe, Maguire, Lindelof, Young, McTominay, Pogba, Lingard, Pereira, James, Rashford.
Subs: Romero, Rojo, Williams, Fred, Mata, Matic, Greenwood.
Arsenal: Leno, Chambers, Sokratis, Luiz, Kolasinac, Xhaka, Guendouzi, Torreira, Pepe, Aubameyang, Saka.
Subs: Martinez, Maitland-Niles, Holding, Willock, Ceballos, Nelson, Martinelli.