Alexandre Lacazette has been dropped to the bench – one of four Arsenal changes.
Dani Ceballos, Nicolas Pepe, Joe Willock and Granit Xhaka are in for Lacazette, Bukayo Saka, Thomas Partey and Mohamed Elneny.
Partey is out with a thigh injury and Elneny has tested positive for coronavirus.
Meanwhile, Kalvin Phillips is back in the Leeds side after a month out with a shoulder injury and Raphinha makes his first Premier League start for the Yorkshire club.
Leeds: Meslier, Ayling, Koch, Cooper, Dallas, Phillips, Alioski, Raphinha, Klich, Harrison, Bamford.
Subs: Casilla, Poveda, Roberts, Costa, Rodrigo, Struijk, Davis.
Arsenal: Leno, Holding, Gabriel, Tierney, Bellerin, Xhaka, Willock, Ceballos, Willian, Pepe, Aubameyang.
Subs: Runarsson, Saka, Lacazette, Maitland-Niles, Mustafi, Nelson, Nketiah.