Bukayo Saka, Leandro Trossard and Reiss Nelson are set to miss Arsenal’s game against Wolves.
All three players are carrying injuries and boss Mikel Areteta has indicated that they will not feature in the final match of the season.
The Gunners were already without Oleksandr Zinchenko, William Saliba and Takehiro Tomiyasu.
Speaking on Friday at his pre-match press conference, Arteta said: “The issues this week are the same as the last few weeks as you noticed, some are unable to play.
“Reiss Nelson has a little issue. Bukayo Saka, Leo has an issue that has been going on for a few weeks.
“Oleksandr Zinchenko is still out, William Saliba is still out, Takehiro Tomiyasu is still out. The rest is all good.”
Saliba’s injury was a huge blow to Arsenal’s title hopes and Arteta is unsure how long he will be sidelined for.
The defender was outstanding earlier in the season and the team looked much less solid without him as Manchester City overtook them to secure another Premier League title.
Areta said: “It is probably too early to say (when Saliba will be fit).
“The injury is evolving in the right way, over the last few weeks. So we are much more positive than the previous two months.
“We wanted to protect him. We want to give him the best possible chance to have a great pre-season.”
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