Arsenal are unchanged from the recent 3-0 win over Southampton.
Emile Smith Rowe is on the bench again, while Pierre-Emerick Aubameyang is not in the squad after being stripped of the captaincy for a discipline breach.
Alexandre Lacazette captains the Gunners.
West Ham boss David Moyes makes just one change, with Pablo Fornals coming in for Said Benrahma, who drops to the bench where he is joined by 19-year-old winger Armstrong Oxo-Flex, who is in the Hammers’ matchday squad for the first time.
Arsenal: Ramsdale, Tierney, White, Partey, Gabriel, Saka, Odegaard, Lacazette, Tomiyasu, Xhaka, Martinelli.
Subs: Okonkwo, Smith Rowe, Maitland-Niles, Holding, Pepe, Tavares, Lokonga, Elneny, Nketiah.
West Ham: Fabianski, Coufal, Fornals, Antonio, Lanzini, Dawson, Bowen, Diop, Masuaku, Soucek, Rice.
Subs: Areola, Yarmolenko, Vlasic, Noble, Benrahma, Kral, Oko-Flex, Alese, Ashby.