Arsenal will be without Henrikh Mkhitaryan for Sunday’s game at the Emirates Stadium.
The Armenia international limped out of Thursday’s Europa League win over CSKA Moscow with a knee problem and will not be fit for the clash with Saints.
Goalkeeper David Ospina (ankle) is also sidelined, as is long-term absentee Santi Cazorla (Achilles), but Pierre-Emerick Aubameyang can return having been cup-tied in Europe.
Provisional squad: Cech, Macey, Holding, Mustafi, Chambers, Bellerin, Koscielny, Mertesacker, Monreal, Nelson, Kolasinac, Maitland-Niles, Xhaka, Elneny, Wilshere, Ramsey, Ozil, Iwobi, Welbeck, Lacazette, Nketiah, Aubameyang.
Southampton’s Mario Lemina faces a late fitness test before their manager Mark Hughes selects his starting XI.
The defensive midfielder is yet to fully recover from a virus but returned to training on Friday and could yet be passed fit. Sam McQueen has already been ruled out, owing to a groin injury.
Provisional squad: Forster, McCarthy, Taylor, Soares, Pied, Bertrand, Stephens, Hoedt, Yoshida, Targett, Lemina, Davis, Romeu, Ward-Prowse, Hojbjerg, Boufal, Long, Redmond, Tadic, Gabbiadini, Austin, Carrillo.
Last season: Southampton 0 Arsenal 2, Arsenal 2 Southampton 1
Last five league matches: Arsenal L L L W W; Southampton L D D L L
Top scorers (all competitions): Alexandre Lacazette (Arsenal) 12; Charlie Austin (Southampton) 6
Referee: Andre Marriner (West Midlands)