Alexandre Lacazette and Alexis Sanchez both start at the Emirates Stadium after being passed fit.
Arsenal striker Lacazette was expected to miss out with a groin injury but plays, while Sanchez has shaken off a minor hamstring problem.
Manchester United have also received a boost, with former Chelsea midfielder Nemanja Matic passed fit to play despite picking up a knock against Watford.
Arsenal: Cech, Koscielny, Mustafi, Monreal, Bellerin, Ramsey, Xhaka, Kolasinac, Ozil, Sanchez, Lacazette.
Subs: Ospina, Mertsesacker, Coquelin, Wilshere, Iwobi, Welbeck, Giroud.
Manchester United: De Gea, Valencia, Lindelof, Smalling, Marcos, Rojo, Young, Matic, Pogba, Lingard, Martial, Lukaku.
Subs: Romero, Darmian, Blind, McTominay, Herrerra, Mata, Rashford.