Jack Wilshere is not in Arsenal’s matchday squad for the game at the Emirates Stadium.
Sead Kolašinac comes into the starting line-up for the Gunners, who are without the injured Nacho Monreal.
Arsenal make four changes in total from Sunday’s Carabao Cup defeat.
Henrikh Mkhitaryan, who was cup-tied, returns along with Danny Welbeck and keeper Petr Cech.
Manchester City are without Fernandinho, Raheem Sterling and the suspended Fabian Delph.
Arsenal: Cech, Bellerin, Koscielny, Mustafi, Kolasinac, Xhaka, Ramsey, Mkhitaryan, Ozil, Welbeck, Aubameyang.
Subs: Ospina, Holding, Iwobi, Chambers, Maitland-Niles, Elneny, Nketiah.
Manchester City: Ederson, Walker, Kompany, Otamendi, Danilo, Gundogan, D Silva, De Bruyne, B Silva, Aguero, Sane.
Subs: Bravo, Stones, Laporte, Jesus, Zinchenko, Toure, Foden.