Youngsters Ainsley Maitland-Niles and Alex Iwobi are both in the Arsenal starting line-up for the game at the Emirates Stadium.
Maitland-Niles, who played in the Carabao Cup win against West Ham, keeps his place in the side.
Meanwhile, Liverpool make two changes to their line-up, with Emre Can and Sadio Mane coming in.
Former Arsenal man Alex Oxlade-Chamberlain is among the Reds’ substitutes.
Arsenal: Cech, Bellerin, Koscielny, Monreal, Maitland-Niles, Xhaka, Wilshere, Iwobi, Ozil, Sanchez, Lacazette.
Subs: Ospina, Mustafi, Kolasinac, Coquelin, Elneny, Walcott, Welbeck.
Liverpool: Mignolet, Gomez, Lovren, Klavan, Robertson, Henderson, Can, Mane, Firmino, Coutinho, Salah.
Subs: Karius, Alexander-Arnold, Milner, Wijnaldum, Oxlade-Chamberlain, Solanke, Lallana.