Thomas Partey, back in the Arsenal squad after a month out with a thigh problem, is among the substitutes for tonight’s derby.
Partey is joined on the bench by Gabriel, who is back following a period of self-isolation after testing positive for Covid-19.
The Gunners make two changes from their last league game, with David Luiz and Ainsley Maitland-Niles coming in for Pablo Mari and Kieran Tierney.
Meanwhile, Ebere Eze is back in the Crystal Palace starting line-up.
Eze comes in for Jeffrey Schlupp – the Eagles’ only change from their last league match.
Arsenal: Leno, Bellerin, Holding, Luiz, Maitland-Niles, Ceballos, Xhaka, Saka, Smith-Rowe, Aubameyang, Lacazette.
Subs: Runarsson, Gabriel, Willian, Cedric, Partey, Pepe, Chambers, Willock, Nketiah.
Crystal Palace: Guaita, Ward, Tomkins, Kouyate, Mitchell, Townsend, McArthur, Milivojevic, Eze, Benteke, Zaha.
Subs: Butland, Van Aanholt, Dann, Ayew, Clyne, McCarthy, Batshuayi, Cahill, Riedewald.