Aaron Ramsey has withdrawn from Wales’ squad ahead of their Nations League encounter against Ireland on Tuesday because of family reasons.
The Arsenal midfielder earned his 56th international cap in the 4-1 friendly defeat to Spain last Thursday, captaining Wales in the second half.
However, the Football Association of Wales announced he will not travel with the squad to Dublin, with Swansea winger Daniel James called up from the under-21s to take his place.
The FAW said in a tweet: “Daniel James has been called up to the senior team from the under 21’s this morning.
Aaron Ramsey will no longer travel with the squad to Dublin due to family reasons.”
Ramsey was allowed to miss Arsenal’s Europa League tie against Qarabag in Azerbaijan earlier this month to stay in London with his pregnant wife.
His personal situation was addressed when manager Ryan Giggs named his 25-man squad for the double header against Spain and the Republic.
Giggs said: “We have to weigh it up and it’s something for us to assess.
“Obviously we are at home for the first game. That’s a plus, but we are just monitoring the situation.”