Arsenal are without Kieran Tierney, but keeper Aaron Ramsdale has been passed fit to return after injury.
Bukayo Saka has recovered from Covid and is also back in the Gunners side.
Crystal Palace make one change from their last league game, with Jordan Ayew coming in for Michael Olise, who picked up an injury on international duty.
Wilfried Zaha has also been nursing an injury but is fit to start.
Crystal Palace: Guaita, Clyne, Andersen, Guehi, Mitchell, Kouyate, Gallagher, Schlupp, Mateta, Zaha, Ayew
Subs: Butland, Ward, Tomkins, Eze, McArthur, Edouard, Milivojevic, Benteke, Hughes
Arsenal: Ramsdale, Cedric, White, Gabriel, Tavares, Odegaard, Partey, Xhaka, Saka, Lacazette, Smith Rowe.
Subs: Leno, Sambi Lokonga, Elneny, Swanson, Holding, Nketiah, Martinelli, Ogungbo, Flores.