Jan Vertonghen is out until at least December with a hamstring injury, Tottenham have confirmed.
The defender was injured in the Premier League win at Huddersfield earlier this month.
Spurs announced on the club’s website: “Jan Vertonghen sustained a hamstring injury against Hudderfield Town on 29 September, which has been monitored closely over the past 12 days.
“Further investigation has shown a good initial response to rehabilitation.
“The Belgium international defender will now continue his recovery with a view to returning to full training by December.
Meanwhile, Danny Rose has pulled out of the England squad through injury, the Football Association has announced.
Gareth Southgate’s side travel a tough Nations League double-header this month, kicking off at Croatia on Friday before heading to Spain.
Rose and Alex McCarthy missed the first training session as a precaution, but the Tottenham left-back and Southampton goalkeeper have now withdrawn from the squad
“Having arrived in camp with minor injuries, @Alex_Macca23 and Danny Rose have now returned to their clubs and won’t feature in this month’s game,” said the post on England’s Twitter account.
🚨 Squad update 🚨
— England (@England) October 11, 2018