West Ham make six changes to the side that beat AZ Alkmaar to reach the Europa Conference League final this week.
Declan Rice, Jarrod Bowen and Lucas Paqueta are among who do start for the Hammers, while Michail Antonio and Saïd Benrahma drop to the bench.
Goalkeeper Lukasz Fabianski and striker Danny Ings are among those recalled to the side.
Leeds, meanwhile, make two changes, with Pascal Struijk and Adam Forshaw replacing Sam Greenwood, who drops to the bench, and the suspended Junior Firpo.
West Ham: Fabianski, Coufal, Zouma, Ogbonna, Emerson, Soucek, Rice, Fornals, Paqueta, Bowen Ings.
Subs: Areola, Johnson, Cresswell, Antonio, Lanzini, Cornet, Benrahma, Kehrer, Mubama.
Leeds: Robles, Ayling, Wober, Struijk, Kristensen, Koch, Forshaw, McKennie, Harrison Bamford Rodrigo.
Subs: Meslier, Cooper, Aaronson, Roca, Summerville, Rutter, Gnonto, Greenwood, Chilokoa.