West Ham boss Manuel Pellegrini makes three changes for the game at the London Stadium.
Pablo Zabaleta and Pedro Obiang are back in along with Andy Carroll, who makes his first start of the season.
New signing Samir Nasri is on the bench.
Brighton make one change, with Florine Andone replaced by Glenn Murray.
West Ham: Fabianski, Zabaleta, Ogbonna, Diop, Cresswell, Snodgrass, Obiang, Rice, Anderson, Carroll, Arnautovic
Subs: Adrian, Noble, Nasri, Masuaku, Perez, Antonio, Diangana
Brighton: Button, Duffy, Dunk, Montoya, Bernardo, Stephens, Gross, March, Propper, Murray, Locadia.
Subs: Steele, Bong, Kayal, Bissouma, Andone, Knockaert, Balogun.