Fabian Balbuena and Javier Hernandez have joined West Ham’s injury list ahead of the trip to Southampton.
Defender Balbuena suffered a knee injury against Watford on Saturday and striker Hernandez came off with back and hamstring problems.
They join Lucas Perez, Marko Arnautovic, Jack Wilshere, Andriy Yarmolenko, Manuel Lanzini, Ryan Fredericks, Carlos Sanchez and Winston Reid on the sidelines.
Provisional squad: Fabianski, Zabaleta, Diop, Ogbonna, Masuaku, Rice, Noble, Snodgrass, Anderson, Antonio, Carroll, Adrian, Cresswell, Obiang, Diangana, Coventry, Silva, Powell.
Southampton will be without midfielder Pierre-Emile Hojbjerg.
Hojbjerg picked up his fifth yellow card of the season late on in Saturday’s 3-1 victory over Huddersfield and must serve a one-match suspension.
Boss Ralph Hasenhuttl is unlikely to make many other changes after seeing his side win two matches in a row.
Teenage striker Michael Obafemi will hope for more game time after becoming Southampton’s youngest ever Premier League scorer on Saturday.
Provisional squad: McCarthy, Gunn, Forster, Soares, Yoshida, Stephens, Vestergaard, Hoedt, Bednarek, Valery, Targett, Davis, Romeu, Lemina, Ward-Prowse, Armst.