West Ham boss David Moyes makes four changes – three of them enforced – for tonight’s FA Cup tie.
Striker Danny Ings is cup-tied, while Vladimir Coufal and goalkeeper Lukasz Fabianski are out injured.
Alphonse Areola comes in in goal and there are also starting places for Emerson Palmieri, Michail Antonio and Pablo Fornals. Jarrod Bowen droppes to the bench.
Manchester United, meanwhile, have made six changes, with Lisandro Martinez, Raphael Varane, Marcus Rashford and Casemiro all on the bench.
Manchester United: De Gea, Dalot, Lindelof, Maguire, Malacia, McTominay, Sabitzer, Fernandes, Antony, Garnacho, Weghorst
Subs: Heaton, Martinez, Varane, Wan-Bissaka, Casemiro, Fred, Pellistri, Elanga, Rashford
West Ham: Areola, Emerson, Ogbonna, Aguerd, Johnson, Paqueta, Rice, Soucek, Benrahma, Fornals, Antonio
Subs: Cresswell, Scamacca, Downes, Bowen, Kehrer, Anang, Swyer, Mubama