Tottenham defenders Toby Alderweireld and Jan Vertonghen have been dropped by boss Jose Mourinho and goalkeeper Hugo Lloris is not in the matchday squad because he has a groin injury.
Mourinho makes four changes in total: Paulo Gazzaniga is in goal and there are recalls for Dele Alli, Serge Aurier and Eric Dier.
Alderweireld and Vertonghen are joined on the bench by Tanguy Ndombele, who has also been dropped from the starting line-up.
Tottenham: Gazzaniga, Aurier, Sanchez, Dier, Tanganga, Davies, Winks, Lo Celso, Alli, Moura, Bergwijn.
Subs: Vorm, Alderweireld, Vertonghen, Parrott, Ndombele, Skipp, Fernandes.
Wolves: Rui Patricio, Boly, Coady, Saiss, Doherty, Neves, Moutinho, Vinagre, Jimenez, Diogo Jota, Traore.
Subs: Ruddy, Neto, Podence, Gibbs-White, Dendoncker, Buur, Kilman.