Tottenham make six changes for the Carabao Cup quarter-final from the 2-2 draw with Liverpool on Sunday.
Matt Doherty, Sergio Reguillon, Oliver Skipp, Pierre-Emile Hojbjerg, Lucas Moura and Steven Bergwijn all come into the side.
West Ham, meanwhile, make four changes, bringing in Alphonse Areola, Harrison Ashby, Ben Johnson and Nikola Vlasic. There is no Michail Antonio in the Hammers’ matchday squad.
Tottenham: Lloris, Doherty, Davies, Dier, Sanchez, Reguillon, Skipp, Hojbjerg, Moura, Bergwijn, Kane.
Subs: Gollini, Royal, Winks, Rodon, Tanganga, Lo Celso, Ndombele, Alli, Son.
West Ham: Areola, Johnson, Masuaku, Diop, Dawson, Ashby, Rice, Soucek, Lanzini, Vlasic, Bowen.
Subs: Randolph, Alese, Fornals, Fredericks, Noble, Kral, Yarmolenko, Benrahma, Baptiste.