Dele Alli and Danny Rose have both been passed fit for Tottenham after recovering from knocks they picked up in the win over Brighton.
Spurs make four changes, with Davinson Sanchez, Eric Dier, Juan Foyth and Ben Davies coming in for Kieran Tripper, Jan Vertonghen, Victor Wanyama and Fernando Llorente.
West Ham make two changes, with Ryan Fredericks and Issa Diop replacing Pablo Zabaleta and Angelo Ogbonna.
Tottenham: Lloris, Davies, Alderweireld, Foyth, Sanchez, Rose, Eriksen, Dier, Alli, Lucas Moura, Son.
Subs: Gazzaniga, Tripper, Janssen, Wanyama, Walker-Peters, Llorente, Skipp.
West Ham: Fabianski, Fredericks, Balbuena, Diop, Masuaku, Rice, Antonio, Noble, Snodgrass, Anderson, Arnautovic.
Subs: Adrian, Zabaleta, Obiang, Chicharito, Wilshere, Ogbonna, Perez.