Heung-Min Son is back in the Tottenham starting line-up following his return from the Asian Cup.
Son replaces Erik Lamela – one of three changes made by Spurs boss Mauricio Pochettino.
Serge Aurier also returns, replacing the dropped Kieran Trippier.
Tripper is joined on the bench by Eric Dier, who is replaced in the side by Davinson Sanchez.
Tottenham: Lloris, Aurier, Alderweireld, Sanchez, Vertonghen, Rose, Winks, Sissoko, Eriksen, Son, Llorente.
Subs: Gazzaniga,Trippier,Dier, Walker-Peters, Moura, Lamela, Skipp.
Watford: Foster, Janmaat, Mariappa, Cathcart, Holebas, Hughes, Cleverley, Capoue, Pereyra, Deeney, Deulofeu.
Subs: Gomes, Britos, Masina, Wilmot, Quina, Sema, Success.