Dele Alli and Christian Eriksen, recently fit again after injury, both start for Tottenham in their crucial Champions League game at Wembley.
Spurs will go out of the tournament if they fail to win and Inter Milan beat Barcelona.
Tottenham: Gazzaniga, Aurier, Alderweireld, Sanchez, Davies, Winks, Eriksen, Alli, Moura, Son, Kane.
Subs: Vorm, Trippier, Walker-Peters, Skipp, Sissoko, Lamela, Llorente.
PSV: Zoet, Dumfries, Schwaab, Viergever, Angelino, Rosario, Hendrix, Pereiro, Bergeijn, De Jong, Lozano.
Subs: Room, Sainsbury, Behich, Ramselaar, Guti, Mauro, Malen.