Danny Rose will miss out for Spurs due to a calf injury.
The left-back picked up the minor problem after playing 90 minutes against Stoke, though his absence is not expected to be lengthy.
Midfielder Harry Winks is in Qatar seeking answers to an ankle injury while defender Kyle Walker-Peters (hamstring) also misses out against the champions-elect.
Provisional squad: Lloris, Vorm, Gazzaniga, Trippier, Aurier, Alderweireld, Vertonghen, Foyth, Sanchez, Davies, Dier, Wanyama, Dembele, Eriksen, Sissoko, Alli, Son, Moura, Lamela, Llorente, Kane.
Manchester City are without top scorer Sergio Aguero due to a knee injury.
Midfielder Fernandinho is also missing through suspension and defender John Stones is still troubled by a thigh problem. Left-back Benjamin Mendy, out since September with knee ligament damage, also remains on the sidelines.
Provisional squad: Ederson, Bravo, Danilo, Walker, Otamendi, Kompany, Laporte, Delph, Zinchenko, Toure, Gundogan, D Silva, B Silva, Sterling, Sane, De Bruyne, Foden, Diaz, Jesus.
Last season: Man City 2 Tottenham 2, Tottenham 2 Man City 0
Last five league matches: Tottenham W W W W W; Man City W W W W L
Top scorers (all competitions): Harry Kane (Tottenham) 35; Sergio Aguero (Man City) 30
Referee: Jon Moss (West Yorkshire)