Dele Alli starts a Premier League game for Tottenham for the first time since Antonio Conte took over as boss.
Tanguy Ndombele and Harry Winks also start, Emerson Royal returns following illness and Ryan Sessegnon starts at left wing-back. Pierre-Emile Hojbjerg is absent from Spurs’ matchday squad.
Liverpool make three changes, with Tyler Morton a surprise inclusion. He’s joined in the side by James Milner and Naby Keita.
Tottenham: Lloris, Emerson Royal, Dier, Sanchez, Davies, Ndombele, Winks, Alli, Sessegnon, Son, Kane.
Subs: Austin, Doherty, Reguilon, Rodon, Lo Celso, Bergwijn, Tanganga, Moura, Skipp.
Liverpool: Alisson, Alexander-Arnold, Konate, Matip, Robertson, Milner, Keita, Morton, Jota, Salah, Mane.
Subs: Kelleher, Firmino, Gomez, Oxlade-Chamberlain, Minamino, Tsimikas, Gordon, Williams, Quansah.