Tottenham boss Jose Mourinho has made three changes, with Sergio Regulion, Harry Winks and Lucas Moura all coming into the starting line-up.
It means Dele Alli drops to the bench along with Ben Davies and Tanguy Ndombele.
Palace make one change to their starting line-up, with Jairo Riedewald replacing the injured James McCarthy.
Wilfried Zaha is back in the squad and among the Eagles’ substitutes.
Tottenham: Lloris, Doherty, Alderweireld, Sanchez, Reguilon, Hojbjerg, Winks, Moura, Bale, Son, Kane.
Subs: Hart, Lamela, Dier, Sissoko, Alli, Bergwijn, Ndombele, Davies, Vinicius.
Crystal Palace: Guaita, Ward, Cahill, Kouyate, Van Aanholt, Milivojevic, Riedewald, Townsend, Eze, Benteke, Ayew.
Subs: Butland, Dann, Zaha, Mateta, Schlupp, Wickham, Batshuayi, Kelly, Hannam.