Injury-hit Tottenham make five changes to their side for the Champions League clash at Wembley.
Spurs are without a number of players, including Dele Alli, Jan Vertonghen and Christian Eriksen, but have goalkeeper Hugo Lloris back.
Mousa Dembele is also among those unavailable because of injury.
As well as Lloris, Ben Davies, Victor Wanyama, Harry Winks and Erik Lamela come into the side.
Eric Dier and Danny Rose are dropped to the bench.
Tottenham: Lloris, Trippier, Alderweireld, Sanchez, Davies, Wanyama, Winks, Lucas, Lamela, Son, Kane.
Subs: Gazzaniga, Rose, Dier, Walker-Peters, Skipp, Sissoko, Llorente.
Barcelona: Ter Stegen, Semedo, Pique, Lenglet, Alba, Rakitic, Busquets, Arthur, Messi, Suarez, Coutinho.
Subs to follow.