Fernando Llorente, supported by Lucas Moura, leads the attack for Spurs, who are are without the suspended Son Heung-min as well as the injured Harry Kane.
Jan Vertonghen returns to the Tottenham side for the Champions League semi-final first leg, as do Kieran Trippier and Victor Wanyama .
Tottenham: Lloris, Trippier, Sanchez, Alderweireld, Vertonghen, Wanyama, Rose, Eriksen, Alli, Moura, Llorente.
Subs: Gazzaniga, Foyth, Walker-Peters, Davies, Dier, Skipp, Sissoko.
Ajax: Onana, Veltman, De Ligt, Blind, Tagliafico, Schone, Van de Beek, De Jong, Ziyech, Tadic, Neres.
Varela, Sinkgraven, Huntelaar, Mazraoui, Magallan, Dolberg, De Wit.