Tottenham have travelled without right-backs Kieran Trippier and Serge Aurier for the do-or-die Champions League clash with Barcelona.
Both are struggling with groin injuries and have not travelled to Spain.
Erik Lamela is fit after a thigh injury and could start as Spurs go into the game having to match Inter Milan’s result against PSV in the final round of Group B matches.
Tottenham midfielder Dele Alli believes victory at Barcelona would be among their best results yet.
Mauricio Pochettino’s Spurs go to the Nou Camp in the Champions League on Tuesday knowing victory would seal a spot in the knockout stages.
They are level on seven points with Inter Milan, who host PSV Eindhoven, in Group B.
Alli scored his 50th Tottenham goal in Saturday’s 2-0 win at Leicester and, after Spurs failed to win their opening three group games, the midfielder feels victory in Spain would be one of the squad’s greatest successes.
He said: “It would definitely be up there. They are one of the best teams in the world, they’ve got some great players and as a kid you dream about playing at the Nou Camp and we’re going to go there and give it our best shot.
“I’ve had a bit of a cold but it’s not too bad.
“A cold won’t keep me out. We’re ready. It’s going to be another difficult game but they’re the games you want to be a part of, playing one of the best teams in the world and some of the world’s greatest players.
“You want to be challenging yourself and we’re going there with the mentality that we can win and we have to believe.
“It’s going to be difficult but we have to go there and give it our best.”