Lucas Moura makes his full debut and Fernando Llorente will lead the attack for Tottenham in the FA Cup fifth-round tie at Rochdale, where Harry Kane is on the bench.
Dele Alli is also among the Spurs substitutes and there is a recall to the starting line-up for Toby Alderweireld.
Kane was passed fit to take his place in the squad despite nursing a knock.
The fit-again Alderweireld makes only his second start since November.
There are also starts for Harry Winks and Victor Wanyama.
Tottenham: Vorm, Trippier, Alderweireld, Foyth, Rose, Wanyama, Winks, Sissoko, Lucas, Son, Llorente.
Subs: Gazzaniga, Sanchez, Walker-Peters, Dier, Alli, Lamela, Kane.
Rochdale: Lillis, McGahey, McNulty, Delaney, Rafferty, Cannon, Camps, Kitching, Done, Humphrys, Henderson.
Subs: Ntlhe, Rathbone, Thompson, Inman, Davies, Moore, Adshead.