Fernando Llorente starts up front alongside Harry Kane for Tottenham.
Danny Rose, back in the squad after a long-term knee problem, is among the Spurs substitutes for the Champions League clash at the Bernabeu.
Ben Davies is ruled out trough illness, so Jan Vertonghen is set to fill in again at left-back.
Real Madrid: Navas, Achraf, Ramos, Varane, Marcelo, Casemiro; Modric, Kroos, Isco, Ronaldo, Benzema.
Subs: Casilla, Nacho, Theo, Lucas V, Llorente, Asensio, Ceballos.
Tottenham: Lloris, Alderweireld, Vertonghen, Sanchez, Aurier, Sissoko, Dier, Winks, Eriksen, Kane, Llorente.
Subs: Vorm, Foyth, Rose, Trippier, Walker-Peters, Georgiou, Son.